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Abstract
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ntroduction: The aim of the present study wa s to determine the effect of exercise training and l-arginine supplementation on kidney and liver injury in rats with MI. Material and methods: Four week s af ter MI, 50 male wistar rats randomly divided into five followed groups: sham surgery without MI (Sham, n = 10), Sedentary-MI (Sed-MI, n = 10 ) 3: L-Arginine-MI (La-MI, n = 10 ) 4: Exercise training-MI (Ex-MI, n = 10 ) and 5: Exercise and l-arginine-MI (Ex + La-MI). Ex-MI and Ex + La-MI groups running on a treadmill for 10 weeks with moderate intensity. Rats in the L-arginine-treated groups drank water containing 4% L-arginine. Tissues oxidative stress and kidney and liver functional indices were measured af ter treatments. Result: Urea as a kidney function indexes, increased in Sed-MI group in compared to sham group and decreased signifi cantly in Ex-MI and Ex + La-MI groups. The level of Cat and GSH of kidney were signi ficantly lower in the MI-groups compared with the Sham group and kidney MDA levels increased af ter MI and signi ficantly decreased in response to aerobic training and L-arginine. As well as, AST and ALT as liver injury indices, increased in MI-groups and decreased by training and L-arginine. In this regards, liver MDA and Cat respectively increased and decreased in MI-groups, but aerobic training and L-arginine increased liver GPX and decreased liver MDA . Conclusion: These results demonstrated that kidney and liver function impaired 14 week s af ter MI and aerobic training and L-arginine supplementation synergistically ameliorated kidneys and liver injury in myocardial infarction rats through oxidative stress reduction.
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