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Title
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Chelating effects of carnosine in ameliorating nickel-induced nephrotoxicity in rats
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Type
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JournalPaper
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Keywords
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carnosine, nephroprotective, oxidative stress, kidney, lipid peroxidation
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Abstract
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The kidney is one of the main organs affected by nickel (Ni) toxicity. We investigated the protective effects of carnosine on Ni- induced oxidative stress in kidney of rats. Animals received NiSO4 (20 mg/kg/day i.g.) and/or carnosine (10 mg/kg/day, i.g.) for 21 days and then were evaluated for biochemical, molecular and histopathological alterations. Ni caused an increase in renal levels of malondialdehydes and a decrease in reduced glutathione, catalase and superoxide dismutase levels and total antioxidant capacity. Carnosine prevented the prooxidant and antioxidant imbalance induced by Ni. Ni-treated rats showed an increase in serum creatinine, urea and uric acid with a concomitant decrease in albumin. Ni markedly accumulated in kidney of Ni-exposed rats and its concentration was effectively reduced by carnosine treatment. Carnosine corrected the biochemical abnormalities and the elevated renal TNF-α and IL-6 levels in Ni group. It also attenuated Ni-induced abnormalities in renal architecture. Although carnosine showed antioxidant and anti-inflammatory effects in renal tissue of Ni-exposed rats, we cannot clearly attribute the protective effect of carnosine to its antioxidant and anti-inflammatory effects. Instead, the beneficial effect of carnosine observed in the current study can be due to the chelation between Ni and carnosine. Thus, carnosine may represent a therapeutic option to protect against Ni-induced nephrotoxicity that deserves consideration and further examination.
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Researchers
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Zhila Felegari (Second Researcher), parisa hasanian (First Researcher)
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