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Title
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Synthesis of b-phthalimido-alcohols via regioselective ring opening of epoxide by using reusable basic magnetic nano particles and their biological investigation
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Type
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JournalPaper
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Keywords
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biological investigation
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Abstract
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In this work, tetra butyl ammonium hydroxide ([Bu4N]OH) and magnetic nano particles (Fe3O4@SiO2@(CH2)3NH2) were introduced as efficient catalysts for the regioselective ring opening of epoxides including aromatic and aliphatic of epoxides to give the corresponding b-phthalimido-alcohols under mild conditions. A various range of b-phthalimido-alcohols as new compounds were prepared and fully characterized by IR, 1H as well as 13C NMR and mass spectra. Also the synthesized compounds were studied for antioxidant properties by DPPH free radical scavenging assay. The results indicated that studied b-phthalimido-alcohols derivatives have effective antioxidant functions (IC50: 0.142–0.356 mg mL1) in compare with BHT (IC50: 0.122 mg mL1) and ascorbic acid (IC50: 0.146 mg mL1) as standards. This may be a new health-care food and drug supplement for special use in the future.
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Researchers
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Mostafa Asadbegy (Not In First Six Researchers), Roya Karamian (Not In First Six Researchers), (Fifth Researcher), Abdolkarim zare (Fourth Researcher), (Third Researcher), First-Name Last-Name (Second Researcher), ma z (First Researcher)
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