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Title
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Inhibitory effect of natural product Parthenolide on α-1-antiprotienase expression in breast cancer cell line
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Type
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Presentation
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Keywords
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Apoptosis, parthenolid, breast cancer
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Abstract
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Our finding demonstrated that Parthenolid could reduce anti-apoptotic protein of α-1-antitrypsin. In this study we introduced a biomarker for early detection of breast cancer. Level of α-1-antitrypsin is elevating in this cancer and it decreased after treatment . Level of α-1-antitrypsin is elevating in this cancer and it decreased after treatment with Parthenolide. Subsequently pro-apoptotic properties of PTL were mediate at two levels: through up-regulation of proapoptotic transcription factors such as bax, p21,puma,bid, bim and p53 expression and through down-regulation of α-1-antitrypsin expression
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Researchers
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Sonbol Nazeri (Second Researcher), sattar tahmasebi enferadi (Fourth Researcher), Reza Behroozi (Third Researcher), (First Researcher)
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