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Title
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Solid phaseextractionofamoxicillinusingdibenzo-18-crown-6 modified magnetic-multiwalledcarbonnanotubespriortoits spectrophotometricdetermination
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Type
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JournalPaper
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Keywords
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Amoxicillin Modified magnetic-multiwalledcarbonna- notubes Removal Preconcentration Spectrophotometricdetermination Solid phaseextraction
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Abstract
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This workreportsonamethodforselectiveextractionandsensitivedeterminationofamoxicillindrug (AMX). ThemethodisbasedonsolidphaseextractionofAMXbyanovelmodified magneticna- noadsorbent priortospectrophotometricdeterminationofAMXusingaprocedurebasedonformationa colored azo-derivativeoftheinvestigateddrug.Thenanoadsorbenthasbeensynthesizedbymodification ofmagnetic-multiwalledcarbonnanotubewithdibenzo-18-crown-6moieties.Thesynthesized nanoparticles werecharacterizedusingTEM,XRDandFT-IRmeasurements.Atthenextstep,various factors thatcouldpotentiallyaffectadsorptionanddesorptionefficiencies ofAMX,havebeenoptimized. The resultsshowedthatundertheoptimizedconditions,sensitiveandselectivedeterminationofthe investigateddruginconcentrationrangeof5.0–1000.0ngmL1 with thelimitofdetectionof 3.0 ngmL1 wasachievable.Furthermore,therealsampleanalysis(i.e.amoxicillincapsulesandhuman urine samples)resultsindicatedthatareliablepromisingcandidatemethodhasbeendevelopedforthe determination ofAMXintheinvestigatedrealsamples.
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Researchers
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Mazaher Ahmadi (First Researcher), Abbas Afkhami (Third Researcher), Tayyebeh Madrakian (Second Researcher)
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