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Title
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Electrografting of 4-tert-Butylcatechol on GC Electrode. Selective Electrochemical Determination of Homocysteine
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Type
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JournalPaper
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Keywords
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4-tert-Butylcatechol · Modified GC electrode · Homocysteine · Electrocatalysis · Surface coverage · Electrografting
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Abstract
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Abstract: A new sensor based on the grafting of 4-tert-butylcatechol on the surface of a glassy carbon electrode (GC) was developed for the catalytic oxidation of homocysteine (Hcy). The GC-modified electrode exhibited a reversible redox response at neutral pH. Under the optimum conditions cyclic voltammetric results indicated the excellent electrocatalytic activity of modified electrode toward the oxidation of Hcy at reduced over-potential about 350 mV. A linear dynamic range of 0.01–3.0 mM and a detection limit of 1.0 mM were obtained for Hcy. The modified electrode was used as an electrochemical sensor for selective determination of Hcy in human blood.
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Researchers
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(Third Researcher), Hamid Salehzadeh (First Researcher), Davood Nematollahi (Second Researcher)
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