|
Title
|
Electrochemical Synthesis of the New Substituted Acetaminophen
|
|
Type
|
Presentation
|
|
Keywords
|
Electrochemical Synthesis of the New Substituted Acetaminophen
|
|
Abstract
|
Electrochemical methods are widely used for the study of electroactive compounds in pharmaceutical forms and physiological fluids due to their simple, rapid, and economical properties [1]. Acetaminophen is a popular, antipyretic and non-steroidal anti-inflammatory drug and its use is one of the most common causes of poisoning worldwide [2]. On the other hand, diarylsulfones are important synthetic targets. They are useful in the practice of medicinal chemistry. Some of diphenylsulfones have been shown to inhibit HIV-1 reverse transcriptase. The importance of these compounds has motivated us to synthesize a number of new diarylsulfones via electrochemical oxidation of acetaminophen The electrochemical oxidation of acetaminophen have been studied in various pH values in the presence of arylsulfinic acids as nucleophiles in aqueous solutions by using cyclic voltammetry and controlled-potential coulometry methods. The results indicate that the N-acetyl-p-benzoquinoneimine derived from oxidation of acetaminophen participates in Michael type addition reaction with arylsulfinic acids to form the corresponding new sulfone derivatives of acetaminophen. The present work has led to the development of a facile and environmentally friendly reagent-less electrochemical method for the synthesis of some new acetaminophen derivatives in aqueous solutions with high atom economy.
|
|
Researchers
|
Davood Nematollahi (Third Researcher), Sadegh Khazalpour (Second Researcher), (First Researcher)
|