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Title
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Water Mediated Domino Knoevenagel-Michael-cyclocondensation Reaction of Malononitrile, Various Aldehydes and Barbituric Acid Derivatives Using Boric Acid Aqueous Solution System Compared with Nano-titania Sulfuric Acid
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Type
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JournalPaper
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Keywords
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Pyrano[2,3-d]pyrimidine dione; Nano-titania sulfuric acid; Boric acid; Barbituric acid; Malononitrile; Aldehyde
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Abstract
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Nano-titania sulfuric acid (TSA) and boric acid [B(OH)3] were efficiently utilized for domino Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives to synthesis of pyrano[2,3-d]pyrimidine diones. It is interesting that in boric acid aqueous solution system, H+ which abstracted from water by the interaction with B(OH)3, efficiently catalyzed the reaction.
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Researchers
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ahmad reza moosavi-zare (Third Researcher), Heidar Ali Alavi Nik (Second Researcher), Ardeshir Khazaei (First Researcher)
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