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Keywords
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Multi-component condensation; 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione (TCCA); 1,3-dichloro-5,5-dimethylhydantoin (DCDMH); 1-thioamido-alkyl-2-naphthol; Solvent-free.
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Abstract
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A new three-component, highly efficient and solvent-free approach for the synthesis of known and new 1-thioamido-alkyl-2-naphthol derivatives was investigated. This was achieved via a one-pot condensation by reacting aryl aldehydes, 2-naphthol, and thioacetamide in the presence of catalytic amount of 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione (TCCA) and 1,3-dichloro-5,5-dimethylhydantoin (DCDMH). Mechanistically, the in situ generation of Cl+ ion from TCCAand DCDMH is proposed to catalyse the reactions in neutralmedia. In the presented work,most of the products have been reported for the first time.
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