|
Title
|
None-catalyst and clean synthesis of symmetric and asymmetric indoles from electrochemical oxidation of 4-aminophenol and p-phenylenediamine in the presence of malononitrile in green media
|
|
Type
|
JournalPaper
|
|
Keywords
|
'electrochemical oxidation' of '4-aminophenol' p-phenylenediamine''malononitrile'
|
|
Abstract
|
The mechanism of electrochemical oxidation of p-phenylenediamine and 4-aminophenol in the presence of malononitrile, as a nucleophile is studied in a phosphate buffer solution (0.15 M) mixed with ethanol (v:v) using the cyclic voltammetry, controlled-potential coulometry and UV-spectroscopy methods. The results obtained indicate that the oxidation form of p-phenylenediamine and 4-aminophenol participate in the 1,4-michael addition reactions with malononitrile via the ECECCC mechanism (E: electrochemical and C: chemical) for the electrochemical synthesis of new indole derivatives with good yield under controlled potential conditions. The products obtained were characterized after purification by the FT-IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis.
|
|
Researchers
|
Davood Nematollahi (Not In First Six Researchers), Mohammad Bakherad (Fifth Researcher), Maryam Rajabi (Fourth Researcher), Sepideh Radmannia (Third Researcher), (Second Researcher), alireza Asghari (First Researcher)
|