Metal − organic frameworks (MOFs) have been previously investigated as electrode materials for developing electrochemical sensors. They have usually been reported to su ff er from poor conductivity and improvement in the conductivity of MOFs is still a great challenge. Here, we reported the fabrication of an electrochemical sensor based on the in situ growth of framework HKUST-1 on conductive graphene oxide nanoribbons (GONRs)-modi fi ed glassy carbon electrode (GCE) (HKUST-1/ GONRs/GCE). The as-fabricated modi fi ed electrode was characterized using fi eld emission scanning electron microscopy, transmission electron microscopy (TEM), high-resolution TEM, Fourier transform infrared, X-ray di ff raction, electrochemical impedance spectroscopy, cyclic voltammetry, and Raman spectroscopy. The voltammetric response of HKUST-1/GONRs/GCE toward Imatinib (IMA), as an anticancer drug, is dramatically higher than HKUST-1/GCE because of the synergic e ff ect of the GONRs and HKUST-1 framework. The calibration curve at the HKUST-1/GONRs/GCE for IMA covered two linear dynamic ranges, 0.04 − 1.0 and 1.0 − 80 μ mol L − 1 , with a detection limit of 0.006 μ mol L − 1 (6 nmol L − 1 ). Taking advantage of the conductivity of GONRs and large surface area of HKUST-1, a sensitive modi fi ed electrode was developed for the electrochemical determination of IMA. The present method provides an e ff ective strategy to solve the poor conductivity of the MOFs. Finally, the obtained electrochemical performance made this modi fi ed electrode promising in the determination of IMA in urine and serum samples.
