Background/ objective: Cisplatin (CP) is a potent drug which, has been used against cancers. Contrary to its antineoplastic activities, CP has many adverse effects such as testicular damages. Reactive Oxygen Species (ROS) is known to provide a mechanism for the pathogenesis of CP-induced testicular damage. Propolis is a honeybee product contains phenolic and flavonoids compounds, which have been shown an antioxidative property. This study aimed to investigate the potentially protective effects of propolis extract on CP-induced testicular damages. Materials and Methods: In this study, 35 male rats were divided into five groups(n=7each). Group1 control. Group2 received single intraperitoneal injections of CP at 5 mg/kg. Groups3 CP+ 100 mg/kg/day propolis (orally). Group4 CP+ 400 mg/kg/day propolis (treatment,serum from all groups were collected for biochemical analysis and sperm parameters including: sperm count, viability and motility were evaluated. Histological evaluation whit eosin and hematoxilyn were performed. Result: This study indicated that sperm count, viability and motility in CP+Propolis group are significantly higher than CP group. Serum testestron level in CP group reduced and propolis ameliorated this reduction. In addition, the propolis treated group showed an improved histological appearance in compared to CP group. Conclusion: In conclusion, it was found that propolis acts as a potent antioxidant agent prevent testicular injury.orally) .Group5 400 mg/kg/day propolis (orally) treatment period was 7 days. After
