Pollution of the environment by toxic metals created stress conditions are generally negatively affected plant growth and development. Cadmium is a highly toxic metal that enters the environment mainly through industrial activities and affected crops and other agricultural plants. In the current investigation, the influence of different concentrations of CdCl2 on Cd uptake, growth parameters, and antioxidant responses of Trigonella foenum-graecum L. plant were investigated. Results showed that H2O2 and malondialdehyde (MDA) contents were increased by Cd treatments compared to control plants. Cd stress differently altered the activity of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and polyphenol oxidase (PPO). The content of antioxidant compounds such as phenol, flavonoid, anthocyanin, soluble protein, and proline was also increased by Cd treatment. In addition, our results demonstrated decrease of seed germination percentage, growth parameters, and chlorophyll and carotenoid contents that may be considered as circumstantial evidence for the toxicity of cadmium.