N,N,N0,N0-Tetrachlorobenzene-1,3-disulfonamide and poly(N,N0-dichloro- N-ethyl-benzene-1,3-disulfonamide) are new catalysts promoted by one-pot, facile and four-component synthesis of new substituted 1,4-dihydropyridine derivatives from the reaction of ammonium acetate, aldehydes and various 1,3-dicarbonyl compounds with good to high yields at room temperature under mild conditions. All the synthesized compounds were evaluated for antibacterial and anti-oxidant activities. Antibacterial activity was determined against four Gram-positive and -negative bacteria, and antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl free radical scavenging. The bioassay results indicated that synthesized 1,4-dihydropyridine derivatives have effective anti-oxidant and antibacterial functions.
