A novel catalyst based on layered double hydroxides coated with copper nitrate [LDH@(3-chloropropyl)trimethoxysilane@N1,N4-bis(4,6-diamino-1,3,5-triazin-2-yl)benzene-1,4-disulfonamide@Cu] was successfully synthesized. The structure of the new synthesized catalyst was investigated and confirmed using different analytical techniques such as Fourier transform infrared spectroscopy (FT-IR), energy scattered X-ray spectroscopy (EDX) mapping, X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), and heat gravity/heat derivatization (TGA/DSC). The skilled catalyst proved its efficiency for one-pot three-component synthesis of pyrano[2,3-d]pyrimidine and new dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine-dione derivatives. Using this efficient catalyst, products were synthesized with a high yield, short time and in soft and solvent-free conditions. The catalyst can be recovered and reused four times without a significant loss of efficiency.
