As a significant class of synthetic and natural products with multiple biological activities, Quinolines are used in medical and electronic devices. Herein, a novel method is presented in order to synthesize 2,4-diarylquinoline derivatives via a simple one-pot multicomponent reaction between phenylacetylenes, aniline derivatives and aldehydes in CH3CN using IRMOF-3/PSTA/Cu. Notably, Polymer/MOF is stabilized through a reaction between a sulfonamide-triazine-based porous organic polymer [poly(sulfonamide-triazine)](PSTA) and an amino-functionalized zinc metal-organic framework (IRMOF-3). Next, the prepared nanocomposites (IRMOF-3/PSTA) are modified using copper iodide nanoparticles (CuI NPs). Overall, the high product yields, facile recovery of nanocatalysts, short reaction times and broad substrate range make this process environmentally friendly, practical and economically justifiable.