Herein, we report the synthesis of the phenyl imidazo[1,2-a] pyridine derivatives at mild conditions using sodium alginate as a green bio-organocatalyst and TBBDA (N, N, N’, N’-tetrabromobenzene-1,3-disulfonamide) as a brominating agent. The desired products were obtained in high to excellent yields with high purities in shorter reaction time under mild reaction conditions.