The three-component reaction between amine, carbonyl compound and thioglycolic acid is now considered as a major strategy for synthesis of 1,3-thiazolidin-4-ones, which consists of the following steps: a) condensation of aldehyde and amine which results in the formation of an imine; b) the reaction between thioglycolic acid and the imine which is followed by an intramolecular cyclization reaction, which leads to the formation of the final product. If any suitable catalyst is employed, the completion of the reaction will not be achieved. Hence, it is of great importance to select an appropriate catalyst so that these compounds can be successfully synthesized. Herein, we employed LDHs@PpPDA as a versatile catalyst for the fabrication of novel derivatives of 1,3-thiazolidin-4-one.
