The multicomponent domino reaction synthesis of dihydro-2-oxopyrroles has been performed using the sulfonated metal–organic framework, UiO-66-SO3H (UiO is the University of Oslo), as a highly efficient acid catalyst. The MOF can act as both Brønsted (H+) and Lewis acid (Zr4+) active sites. The protocol presents an environmentally benign as well as a simple experimental and work-up procedure.
