Integro‐differential equations with non‐integer order derivatives are an all‐purpose subdivision of fractional calculus. In the current paper, we present a numerical method for solving fractional Volterra‐Fredholm integro‐differential equations of the second kind. To establish the scheme, we first convert these types of integro‐differential equations to mixed integral equations by fractional integrating from both sides of them. Then, the discrete collocation method by combining the locally supported radial basis functions are used to approximate the mentioned integral equations. Since the local method proposed in this paper estimates an unknown function via a small set of data instead of all points in the solution domain, it uses much less computer memory in comparison with the global cases. We apply the nonuniform Gauss‐Legendre integration rule to compute the singular‐fractional integrals appearing in the scheme. As the scheme does not need any background meshes, it can be recognized as a meshless method. Numerical results are included to show the validity and efficiency of the new technique and confirm that the algorithm of the presented approach is attractive and easy to implement on computers.