Medicinal plants are widely used in treatment of diseases in the world. Diabetes mellitusis one of the common metabolic disease which has variousbody disorders. This study was conducted to evaluate the effects of intraperitoneal administration of Satureja montanaleaf hydroethanolic extract (SME) on the serum glucose levels in diabetic male rats. In this experimental study 42 male rats were divided randomly in 6 groups contain control group, diabetic and diabetic treatment with SME extract (200mg/kg, 400mg/kg and 800mg/kg,i.p) and diabetic treated with metformin (500mg/kg,gavaged). The blood glucose were examined daily by glucometer after induced with STZ and treatment by SME. All data were analyzed using one-way ANOVA and then Tukey post test and all data were expressed as mean±SEM. and statistical significance differences were accepted at P<0.05. Intraperitoneal prescription of hydroethanoholic extract of Satureja montana significantly caused decrease blood sugar in diabetic rat (P< 0.05), but it has not effect on normal rats. The rats which treated with 800mg/kg SME were more significantly decreased glucose serum level compared with control group (P<0.001). The metformin administration had decreasing effect on blood glucose level but it effect was moderate compared with SME treatment in diabetic rats.The SME has hypoglycemic effects in diabetic rats. It seems that the Satureja montanahas some natural chemical composition and ant oxidants which can decrease blood glucose level and increase insulin hormone.
