The chemical toxins caused hematopoiesis disorders and changed blood parameters. Medicinal plants have hematopoietic effects and can inhibit the toxicity progress in blood tissue. In this study the protective effect of Avicennia marina leaf extract (MLE) on hematopesis in male rat were induced with carbon tetrachloride investigating.The 42 male rats with 220-250 gr body weight were divided randomly in 6 groups(n=7): control (taking normal saline,0.5ml/day, i,p ), sham(taking olive oil, 0.5ml/day, i,p single dose),group induced by ccl4 (carbon tetrachloride 1:1 with olive oil,0.5ml single dose, i,p), treated groups: (1,2 and3 by carbon tetrachloride 1:1 with olive oil,0.5ml single dose and 200mg/Kg, 400mg/Kg and 800mg/kg MLE /day for 96 hrs, i,p). After the examination the blood samples were collected from heart directly and RBC,WBC,PL,Hb,MCV,MCH,MCHC, total protein and Albumin were analyzed and the microscopic studies of bone marrow tissue were done. All data were expressed as mean±SEM. and statistical significance differences were accepted at P<0.05.Our results showed that the carbon tetrachloride has necrotic effect in bone marrow. The RBC, MCV,Hb and Hct has no changed compared with control group (P>0.05). The WBC, PL, total protein and albumin were increased significantly compare to ccl4 induced group (P<0.001). The serum total bilirubin level decreased significantly in treatment groups (P<0.05). The Avicennia marina hydroethanolic extract has antioxidant and flavonoids compounds which can protect the hematopoietic tissues from toxic agents such as ccl4.[1, 2, 3].
