Diabetes mellitus is one of the most common metabolic disorders, which is accompanied by debilitating complications in the long term. This study was conducted to evaluate the effects of intraperitoneal administration of Anethum graveolensleaf hydroethanolic extract (AGE) on the serum glucose levels in diabetic male rats. In this experimental study 35 male rats were divided randomly in 5 groups contain control group, diabetic (STZ 60mg/kg, i.p), diabetic treated with metformine (500mg/kg, gavaged) and diabetic treatment with AGE extract (200mg/kg and 400mg/kg ,i.p). The blood glucose were examined daily by glucometer for one week and data were analyzed using one-way ANOVA and then Tukey post test.All data were expressed as mean±SEM and statistical significance differences were accepted at P<0.05. Intraperitoneal Prescription of hydroethanoholic extract of Anethum graveolens significantly decreased blood sugar in diabetic rats (P<0.001). The rats which treated with 400mg/kg AGE were more significantly decreased glucose serum level compared with control group (P<0.001). The metformine administration had decreasing effect on blood glucose level but it effect was moderate compared with AGE treatment in diabetic rats.The AGE has hypoglycemic effects in diabetic rats. It seems that the Anethum graveolenshas some flavonoids and trepenoids composition that can decrease blood glucose level and increase serum insulin
