Drugs and chemical agents may infect on kidney tissue and caused renal toxicity. Carbon tetrachloride which is used in hygiene industries caused renal disorders. Medicinal plants are able to protect body organs. In this study the protective effect of Avicennia marina leaf extract (MLE) on renal function in male rat were induced with ccl4 investigating. The 42 male rats with 220-250 gr body weight were divided randomly in 6 groups (n=7). control (taking normal saline,0.5ml/day, i,p ), sham(taking olive oil, 0.5ml/day, i,p single dose), group induced by ccl4 (carbon tetrachloride 1:1 with olive oil,0.5ml single dose, i,p), treated groups: (1,2 and3 by carbon tetrachloride 1:1 with olive oil,0.5ml single dose and 200mg/Kg, 400mg/Kg and 800mg/kg MLE /day for 96 hrs, i,p). After the examination the blood samples were collected from heart directly and BUN, serum creatinine, LDH , ALT,AST and ALP enzymes were analyzed and the microscopic studies of renal tissue were done. All data were expressed as mean±SEM. and statistical significance differences were accepted at P<0.05. Our results showed that the carbon tetrachloride has necrotic effect on kidney. The BUN,LDH and liver enzymes increased in group which induced with ccl4 compared with control group and treated groups by MLE have decreased liver enzymes compared with ccl4 induced group significantly (P<0.001). The microscopic study of kidney tissue showed that the necrosis and inflammation in glumerolus and renal tubules (P<0.001) and treated groups were no changed.The Avicennia marina hydroethanolic extract has antioxidant and flavonoids. compounds which can protect the kidney tissues against toxic chemical agents .[1, 2, 3, 4]
