Material engineering has attracted a lot of scientific attention among scientists in recent years. Meanwhile, metal-organic frameworks (MOFs) are a promising class of engineered materials. The ability to design and target synthesis, attractive porous architecture and flexibility are among the characteristics of these crystal structures, which are obtained by connecting organic ligands to metal clusters. The attractive nature and properties of MOFs have caused these crystalline porous materials to have potential applications in sensors, drug delivery, gas absorption, catalysts, and photocatalysts [1]. Nowadays, green and low-cost synthesis of organic compounds has become an attractive challenge. Therefore, an attractive approach in this field is the synthesis of organic and pharmaceutical compounds with the help of MOFs catalyst, which provide a suitable platform for chemical reactions. Expanding the potential capabilities of MOFs in Click reactions and especially the synthesis of triazole compounds is a very attractive scientific approach [2]. Therefore, in this report, Fe-MOF@CuO, which is a MOF modified with CuO, was designed and its capability in the preparation of triazole derivatives was measured. Triazole compounds are very important because of their medicinal and biological properties, such as antibacterial, antifungal, etc. [3]. This was a strong motivation for us in this research (Scheme 1).