In the last decade, significant progress has been made in the field of porous materials. Metal-organic frameworks (MOFs) are an amazing example of porous materials. The crystalline structure along with adjustable pores has made this category of porous compounds to be used in many fields, such as drug delivery, catalyst, photocatalyst, sensor and gas absorption [1]. The use of MOFs as a catalyst has attracted widespread scientific interest among scientists. Therefore, many organic compounds have been synthesized with the help of MOFs catalyst. Heterocycles are an important class of organic compounds that are widely used in the pharmaceutical, agricultural, and dye industries. Pyrazolo[3,4-b]pyridines have many medicinal and biological properties, such as anti-cancer, anti-bacterial, anti-fungal, etc. [2]. Therefore, for the synthesis of new pyrazolo[3,4-b]pyridines with biological cores, the Zr-MOF@Cu(OAc)2 catalyst, which has a metal-organic framework support, has been used. These materials are synthesized under solvent-free conditions at 100 °C. The high reaction rate, short reaction time, high product yield, and catalyst separation capability are important features of the above research, which show the value of introducing this catalyst (Scheme 1).
