In the quest for the best catalytic materials, metal-organic frameworks (MOFs) have garnered significant attention. MOFs are a class of porous materials composed of metal ions or clusters interconnected by organic ligands [1-2]. The importance of multi-component reactions with diversity in raw materials as well as click reactions as an important group of material coupling methods has been well defined and the need to improve synthesis conditions and perform such reactions in terms of their environmental and economic efficiency is very important [3]. The main goal of this report is to discuss the expansion of click chemistry. In the present study, a new metal-organic framework was designed and synthesized. In the design of the catalyst, it was tried to place CuO nanoparticles on the Zn-MOF so that the properties of both CuO and Zn-MOF can be used. This catalyst was used to synthesize 1,4-other substituted-1,2,3-triazoles derivatives. The method represents a truly green process with good sustainability and economics (Scheme 1).