A new H-bond Ti-MOF-based catalyst via the post-modification method of metal-organic frameworks (MOFs) was synthesized. The catalytic role of Ti-MOF-UR is based on hydrogen-bond interaction. Ti-MOF-UR was used to synthesize pyrazolo[3,4-b]quinolines and pyrazolo[4,3-e]pyridines that contain the biological nuclei of pyrazole, henna and coumarin. The structure of the synthesized catalyst as well as the pyrazolo[3,4-b]quinoline and pyrazolo[4,3-e]pyridine derivatives were approved by using various instrumental techniques such as melting point, FT-IR, 1 H NMR, 13C NMR and HR-MS techniques.
