2-amino-3-cyano pyridines are a very prominent series of the heterocyclic component as they represent the exceptional pharmacological role [1]. On the other hand, multicomponent reactions (MCRs) are becoming important instruments in the new synthesis chemistry due to their efficiency, economic benefits, green synthesis and ease of formation of various new compounds in one-pot reactions, which operated effective characters in developing the green chemistry and complex structures [2]. In recent years, the use of magnetic nanocatalysts has become attractive due to separation and reusability [3]. In this context, we report the synthesis of 2-amino-3-cyano pyridines via a one-pot four-component reaction of arylaldehydes, malononitrile, ammonium acetate and (methyl ethyl ketone or methyl isobutyl ketone) by use of a highly efficient magnetic catalyst, the reaction proceeds with high yield under solvent-free conditions then the catalyst could be separated from the reaction mixture by use of an external magnet (Figure 1).
