Magnetic nanoparticles have been studied in various fields such as medicine, drug delivery and catalyst due to their high potentials [1]. The most prominent features of multicomponent reactions include good selectivity, high atomic economy, synthesis of complex molecules with the least possible by-product, simplicity and efficiency of the protocol. Multicomponent reaction strategy has been able to provide powerful methods for the synthesis of drugs and biological compounds, polymers, supramolecular systems and molecular machines [2]. We used urea-containing magnetic nanoparticles as a highly efficient recyclable acidhydrogen bond catalyst in the synthesis of new pyridine compounds. Catalyst characterization was performed using a variety of techniques, including FT-IR, 1H-NMR, 13C-NMR, EDS, FESEM, TEM, TGA, VSM, and elemental mapping analysis. Then the multi-component reaction is performed using catalyst under solvent-free conditions. This method has the advantages of high efficiency, short reaction time, mild reaction conditions for the synthesis of pyridine compounds and suitable recyclability.
