Nowadays, the design of biological catalysts that are in line with the environment and green chemistry is an appreciable perspective and deserve more attentions. Deep eutectic solvents supported on the nanomagnetic particles are an example of this catalytic systems. These materials because of their dual acidic and hydrogen bonding functional groups and ability of chelate formation with metals can be used as a robust multifunctional catalytic system [1-2]. There are several advantages for these systems that are including of the synthesis of high-efficiency products, short reaction time and ease of operation [3]. Pyranopyrazoles as one of the most preeminent classes of heterocyclic compounds have a key role in biological and pharmacological domains. Several medicinal applications such as antimicrobial, anticancer, anti-inflammatory and inhibitors of human Chk1 have been devoted for pyranopyrazole derivatives [4-5]. In a deliberate study, catalytic application of urea derivatives-linked choline chloride functionalized magnetic nanoparticles as new deep eutectic solvent systems was investigated for the synthesis of pyranopyrazole derivatives (Scheme 1).
