Nowadays, metal-organic frameworks (MOFs) have known as a unique type of porous solid materials, because they have been utilized in different fields such as drug delivery, catalyst, battery, super capacitor, sensor, gas storage, separation and adsorption of molecules [1]. These materials consist of multifunctional organic materials bind to metal or metal clusters through coordinated components such as carboxylates to form crystalline materials with high surface area and high thermal stability [2]. Heterocyclic compounds containing N and/or O heteroatoms show biological properties [3]. Therefore, the attention of many scientists has been attracted to the synthesis of these compounds. Also, tetrahydropyrido[2,3-d]pyrimidines are a well-known group of these compounds that show great importance biological properties like adenosine kinase inhibitors, anti-tumor, antifungal, antibacterial, anti-proliferative CDK2 inhibitor, antipyretic, anticonvulsant agents, analgesic and also used in CNS depressant activity [4]. In this work, we have synthesized novel tetrahydropyrido[2,3-d]pyrimidines via vinylogous anomeric based oxidation mechanism (Scheme 1).
