Metal-organic frameworks consists of organic compound as ligand and metal that make large surface area, high flexibility and pore size planning namely metal-organic frameworks (MOFs). These porous materials was applied as gas storage and separation, drug delivery, sensors, batteries, supercapacitors as well as catalyst [1]. Historically, anomeric effect (AE) was introduced by J. T. Edward on the development of organic chemistry. This hypothesis, which is propagated through double bonds, has been termed as a vinylogous anomeric effect (VAE) [2]. Anomeric based oxidation (ABO) concept has been known for the final step of oxidation/reduction mechanism in the preparation of biological compounds [3]. The development of cooperative vinylogous anomeric-based oxidation (CVABO) is at the forefront of organic chemistry due to the importance of this concept in promoting the synthesis of organic compounds with biological properties [4]. Also, fused N-heterocycle compounds such as pyrazolo[3,4-b]pyridines may be suitable candidates for biological and pharmacological activity [5]. According to the above-mentioned idea, we have designed and synthesized of novel heterogeneous and porous complex based on Zr-MOFs. This porous complex was applied for the synthesis of pyrazolo[3,4-b]pyridine derivatives by condensation reaction of various aromatic aldehydes (bearing electron-donating and electron-withdrawing groups), ethyl cyanoacetate and 3-(4-chlorophenyl)-1H-pyrazol-5-amine via cooperative vinylogous anomeric-based oxidation under solvent-free condirion at 100 °C (Scheme 1).
