Nowadays, porous and magnetic materials have been widely used in biotechnology, magnetic resonance imaging (MRI), catalysis, adsorption, gas separation and purification, optics, drug delivery and etc. [1-2]. Metal-organic frameworks (MOFs) are widespread strategy for the expansion of new porous materials to reach with higher surface area. By selecting rational strategy, materials (metal centers and ligands) and suitable reaction condition can be precisely tuned and the spatial cavity arrangement precisely controlled. By joining of magnetic materials (Fe3O4) and metal-organic frameworks (MOFs) become powerful tools in the synthesis of new task-specific catalysts [3]. According to the above mentioned idea, we have synthesized MMOFs-PO3H2 as a nanoporous and magnetic catalyst. A good range of pyrido[2,3-d]pyrimidines were prepared by reaction of uracils, 3-methyl-1H-pyrazol-5-amine and aldehydes in the presence of described catalyst via a cooperative vinylogous anomeric based oxidation mechanism under solvent-free conditions
