Among heterocyclic scaffolds, multisubstituted cyclohexa-1,3-dienamines and their derivatives are unique. These heterocyclic molecules, represent diverse biological and pharmacological applications and well distributed in naturally-occurring compounds. Also, they are key synthetic intermediates. On the other hand, among heterogeneous catalytic systems, magnetic nanocatalysis presents a catalytic system which shows suitable activity, selectivity, easy separation and recovery. The paramount goal of one-pot multicomponent reactions, are the effective and rapid synthesis of target molecules accompanied with economic and ecological insight [1-3]. In this study, we combined the merits of magnetic nanocatalysis and multicomponent reactions and represent a mild protocol for the synthesis of multisubstituted cyclohexa-1,3-dienamines by using a pseudopolymeric magnetic nanoparticles (Figure 1).
