In the current study, a novel and reusable biological urea based nano magnetic catalyst namely Fe3O4@SiO2@(CH2)3‐urea‐benzimidazole sulfonic acid was designed and synthesized. The structure of the titled catalyst was fully characterized using several skills including Fourier transform infrared (FT‐IR) spectroscopy, energy dispersive X‐ray (EDX) analysis, X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo gravimetric analysis/differential thermal analysis (TG/DTG) and vibrating sample magnetometer (VSM). Then, the catalytic performance of Fe3O4@SiO2@(CH2)3‐urea‐benzimidazole sulfonic acid was successfully inspected towards the multicomponent synthesis of 2‐amino‐3‐cyano pyridine derivatives through a vinylogous anomeric based oxidation pathway. Highlights: Fe3O4@SiO2@(CH2)3‐urea‐benzimidazole sulfonic acid as a novel catalyst was designed, synthesized and fully characterized. The described catalyst was applied as elegant catalyst for the facile preparation of new 2‐amino‐3‐cyano pyridines through a vinylogous anomeric based oxidation pathway. The mentioned catalyst shows high potent of recovering and reusing capability.
