Phosphoric acid as a non-toxic acid is extensively using in the chemical industry such as: food industry, medicine, soldering, cleaning agents and the printing industry [1]. Due to the properties and use of phosphoric acid, the synthesis of a new catalyst based on this acid is great of demand [2]. One of the most important heterocyclic rings, which are presenting in a wide range of compounds, due to thier properties such as anticancer, anti-HIV, antimicrobial, anti-inflammatory and calcium channel antagonist activity [3, 4]. In the present work, we wish to report an efficient and eco-friendly three-component reaction condensation protocol in refluxing water and neutral media using ionic liquid with dihydrogen phosphate anions (5 mol%) as catalyst (Scheme 1).
