Deep eutectic solvents (DESs) rapidly emerging in the domain of green chemistry area as green alternatives for hazardous and volatile common organic solvents. These compounds represent varied merits including availability, non-toxicity, biodegradability, recyclability, flammability, and inexpensive [1-2]. On the other hand, linked pyridine derivatives are ubiquitous within the nature and have a significant location in the pharmaceutical and medicinal industries and can applied for different goals such as anti-tumor, analgesic, anti-inflammatory, antipyretic, anti-microbial and cardiotonic activities [3]. In this investigation, we present an .elegant strategy for the preparation of linked pyridine derivatives using biological based DES
