In recent years, metal–organic frameworks (MOFs) have been considered as a new category of nano-porous materials which are suitable for storage and separation of gases, catalysts, heavy metal adsorbents. MOFs, based on the type of ligand and functional groups on their surface, exhibit various properties. MOFs exhibit a unique catalytic role in the preparation of hydrogen and methane gas and the synthesis of a wide range of chemical and pharmaceutical compounds [1-2]. N-Amino-2-pyridones and 1,4-dihydropyrano [2,3-c]pyrazoles have been applied to the treatment of rheumatoid arthritis, psoriasis, cancer, Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, Down’s syndrome, AIDS, schizophrenia, and myoclonus as well as demonstrating biological properties such as antiviral, , pheromonal, and central nervous system activity [3-4]. In this work, we have designed and synthesized a MOF, MIL- 101(Cr), as an efficient catalyst for promoting the described four components reactions under refluxing water conditions
