In this work, a convenient multi-component reaction towards the synthesis of spiropyran derivatives catalyzed was described using SBA-15/(CH2)3N(CH2PO3H2)(CH2)2-N(CH2PO3H2)2 as a novel efficient, recyclable and nanostructured catalyst in water under reflux condition. The main advantages of the offered methodology are notable yields, short reaction times and the reusability of the catalyst. This catalyst was also tested in large scale to investigate it for using in industrial applications which had remarkable results.
