One series of DHP derivatives with an improved structural scaffold, the hexahydroquinoline derivatives (HHQs), can be synthesized according to a Hantzsch synthesis using aryl aldehydes, dimedone (5,5‐dimethylcyclohexane‐1,3‐dione), ethyl acetoacetate, and ammonium acetate in a one‐pot multi‐component condensation reaction [1, 2]. Quinolines bearing a 1,4‐dihydropyridine scaffold have been identified as promising structure in medicinal chemistry because of their many pharmacological properties, including their antibacterial antihypertensive, anti‐inflammatory, antimalarial, antiasthmatic, and tyrosine kinase inhibitory activity [3–8]. In this methodology we have reported the synthesis of hexahydroquinolines using nano APVPB as reusable catalyst (Scheme1). The promising points for the presented methodology are efficiency, generality, high yields, very short reaction times, cleaner reaction profile and simplicity.
