In recent years, the design and application of biological-based catalysts in organic synthesis and functional groups transformation have attracted intensive attention in the science and industry because of their unique properties, such as biodegradable ability, efficiency, reusability, reactivity, stability, selectivity, and easy separation of the catalyst.1 In continuation of our investigation for developing biological based catalysts, we wish to introduce a novel nano magnetic catalyst with phosphorus acid tags. Magnetic catalysts have been used for the synthesis of a good range of pharmaceutical and chemical compounds, due to their easy removal and convenient separation. The reported catalysts can be easily isolated from the reaction mixture with an external magnetic field.2 Magnetic catalysts are usually made of magnetic nanoparticles such as iron oxide nanoparticles (Fe3O4) or other magnetic nanoparticles to which various catalytic materials such as precious metals or organic compounds are attached.3 Fe3O4@MHMHPA as new catalyst containing phosphorus acid tags will be used in the synthesis of new pyrazolo[3,4-b]pyridines to determine the importance of its synthesis. Synthesized pyrazolo[3,4-b]pyridines can be suitable candidates for medical and environmental uses due to the presence of biological nuclei.
