Metal-Organic Frameworks (MOFs) have gained significant attention in the field of solid-state chemistry over the past two decades. These promising materials have various applications, including gas adsorption, separation, catalysis, sensing, and drug delivery. Among the research areas in crystalline materials, Pillar-layered Metal-Organic Frameworks (MOFs) stand out. Exploring their diverse structures, properties, and potential as multi donor porous frameworks is of great interest due to the numerous reports on pillar-layered MOFs. By modifying the pillar moieties along with metal nodes and oxygen donor linkers, it is possible to improve control over structure assembly and obtain structures with specific properties. The incorporation of the pyridine ring system into the structure of bioactive compounds is quite popular among N-heteroaromatics. This ring system is also found in natural products like nicotinic acid, nicotinamide, and vitamin B6, which play crucial roles in metabolism. (Scheme).
