An efficient and simple multicomponent method for the synthesis of new indolyl-pyridines bearing sulfonamide moiety, as multi-functional heterocycles, through a condensation reaction of 3-cyanoacetyl indole, N-(4-acetylphenyl)-4-methylbenzenesulfonamide, aryl aldehyde, and ammonium acetate in the presence of Fe3O4@ SiO2@(CH2)3-urea-quinolinium trifluoroacetate as a novel and recyclable nanomagnetic catalyst, under solvent-free conditions is developed. The novel catalyst was characterized using Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy equipped by energy dispersive spectroscopy, X-ray diffraction, elemental mapping analysis, transmission electron microscopy, thermo gravimetric analysis/derivative thermo gravimetric and vibrating sample magnetometer. We suggested a cooperative vinylogous anomeric-based oxidation as a mechanistic route for the last step of the described synthesis. A simple procedure, high proficiency, and recyclability of the catalyst are the most attractive features of this protocol.
