Heterogeneous catalysis due to unique perspective in the areas of chemistry increasingly have been considered by researchers. On the other hand, magnetic nanoparticles (MNPs) as a preeminent subset of heterogeneous catalyst are a useful strategy in many of catalytic reactions [1-3]. MNPs, with high surface area, durability, low toxicity, designability in modification and decoration and easy synthetic procedure are suitable for catalytic processes [4-5]. One of the main applications of MNPs is in multi-component reactions. This strategy with excellent selectivity, efficiency, high atom economy, ideal synthetic routs for complex molecules and simplicity is a foreceful methods for the synthesis of biological and pharmaceuticals compounds [6-9]. 2-Aminothiophene scaffolds derived from Gewald reaction have been attracted the great attention of many researchers [10-12]. These compounds have pivotal role as intermediates of organic synthesis and have many applications in medicinal chemistry, agrochemicals, dyes, and biologically active products [13-15]. Therefore, we focused on the synthesis of 2-aminothiophene derivatives in the presence of urea-benzoic acid functionalized magnetic nanoparticles namely Fe3O4@SiO2@ULB as efficient and green heterogeneous catalyst.
