Nowadays, research and development (R&D) based on the presentation of new strategy is essential for the synthesis of organic compounds without the use of catalysts, hazardous solvents, toxic chemical materials, easy reaction conditions and etc [1]. On the other hand, extension the principles of green chemistry are one of the main goals of organic chemistry. For this purpose, ammonium acetate (NH4OAc( is known as a green, non-toxic and safe compound, which has been applied as a source of nitrogen for the synthesis of N-heterocycle compounds. Also, NH4OAc can also applied as efficiently and eco-friendly catalyst in the synthesis of organic compounds [2]. Indole compounds are an important group of heterocycle compounds that have received much attention due to their unique properties. This compounds and especially their bis structures have important inhibitory effects on leukemia, ovarian cancer, non-small cell lung cancer, breast cancer, colon cancer and kidney cancer [3-4]. Due to the attractive strategy of using ammonium acetate as a dual rule reagent-catalyst in the synthesis of biological active organic molecules, catalytic application of ammonium acetate was investigated for the synthesis of bis(3-indolyl) pyridine derivatives via cooperative vinylogous anomeric based oxidation (CVABO) concept. Herein the synthesis of biological derivatives without the use of toxic and expensive materials was occurred (Scheme 1).
