We wish to reply to the illogical comments presented on the above mentioned paper titled as “the main problems related to the definitions of conformation, configuration enantiomerism, epimers, diastereomerism, invertomerism, conjugation, hyperconjugation, s-conjugation and anomerism” addressed by Dr. Salehzadeh and his colleague. The response includes: i) the X-ray (experimental) and theoretical reported results of the empimerism and their differences on the stereoisomerism properties, which are definitely not matched with enantiomers and conformers, ii) the introduced MBO method of the bond orders in different pathways of the resonance process, iii) the standard enantiomerism, epimerism, diastereomerism, invertomers, anomeric effect and hyperconjugation definitions, iv) the importance of the small changes of bond length effect on the bond order and chemical properties, v) the structure of HBF4.H2O cluster, and vi) the discussion regarding internal molecular orbital (MO) electron transfer. © 2018 Published by Elsevier B.V. 1. Introduction Recently, some comments on “A convenient method for preparation of 2-amino-4,6-diphenylnicotinonitrile using HBF4 as an efficient catalyst via an anomeric based oxidation: A joint experimental and theoretical study” (J. Mol. Struct., 1137 (2017) 674e680) [1]
