As an emerging class of highly ordered crystalline porous materials, metal-organic frameworks (MOFs) with various potential applications have become a new research hotspot in chemistry and materials during the last few decades, which is mainly attributed to their exceptionally high surface area, tunable pores, as well as intriguing functionalities [1]. Some advantages of these porous materials are high surface area, and thermal stability of their chemical structure [2]. The improvement in the stability of MOFs can expand their applicable fields, and make them applicable on the other topics such as catalysis, adsorption and separation, and biomedicine. Zirconium is widely distributed in nature and is found in all biological systems. The rich content and low toxicity of Zr further favor the development and application of Zr- MOFs. Hantzsch 1,4-dihydropyridines (1,4-DHP) are an important class of compounds with vital medicinal value which are used for the treatment of cardiovascular disease such as hypertension and angina pectoris [3]. Indole nucleus is a prominent structural subunit present in many naturally occurring compounds that possess significant pharmacological and biological properties. A number of indole derivatives having heterocycles at the 3-position have been obtained from nature with potential biological activity [4]. Herein, the nano Zr-based MOFs utilized as an efficient and reusable catalyst for the synthesis of a wide range of dihydropyrido[ 2,3-d]pyrimidine compounds
