One of the interesting choices for the heterogenization of the homogeneous catalysts is the stabilization of catalytic active structure onto the surface of magnetic nanoparticles such as Fe3O4 nano particles. This process is an efficient strategy to overcome difficulties connected to cumbersome process of isolation and separation of the homogeneous catalytic system [1-2]. On the other hands applying one-pot multicomponent reactions strategy for the rapid synthesis of target molecules accompanied with economic and ecological insight in highly valuable [3]. In this investigation we combined excellent merits connected with nano magnetic heterogeneous catalysts and one-pot multicomponent reactions strategy and present an applicable .route for the synthesis of quinoline-3-carbonitrile derivatives under mild reaction conditions