Classification of basic concepts is one of the major duties of the scientists toward common readers. The origin of the anomeric effect has been a matter of debate, so that there are contradictory approaches for this subject. Very recently, Wiberg et al. have published an excellent paper entitled "The anomeric effect: Its complicated" [1]. Nevertheless, further investigations of this important effect are still required [2]. To the best of our knowledge, the origin of the anomeric effect is not a consequence of an effect alone, but it is the result of the several factors, which it is working together. The identifying between stereoelectronic interactions is a major problem (none bonded repulsion and so on), hyperconjugation (negative, positive and neutral) and anomeric effect (endo, exo and reverse) that may be confused by readers. Sharing the electron density from an anion and/or none bonded lone pair(s) electrons into the vacant anti-bonding (*) orbital was known as negative hyperconjugation. Intramolecular negative hyperconjugation is also known as anomeric effect. Each type of stabilizing due to interaction between a sigma bond with donors or acceptors was known as hyperconjugation interactions. Aomeric conjugation (donation from a lone pair to the vicinal sigma* orbital) is an example of hyperconjugation (conjugation that involves a sigma bond). All of the terms of conjugation, hyperconjugation, -conjugation and anomeric effect are often recognized as resonance in modern scientific literatures [3-4]. Recently we have introduced a new concept entitled of "anomeric based oxidation" (ABO) which has opened a new synthetic and theoretical insight for the design, synthesis and applying the organic molecules that are important in medicinal and biological activities [5]. The "anomeric based oxidation (ABO)" mechanism is in good agreement with the previous reported "vinylogous anomeric effect" studies
